This past Friday and Saturday, U.S. Customs and Border Protection officers at Arizona’s Port of Nogales arrested two Mexican national men for attempting to smuggle drugs across the border.

Both arrests had no correlation and were two separate attempts.

The U.S Customs and Border Protection says they were notified of both threats, "after a CBP narcotics detection canine alerted to an odor it was trained to detect."

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[RELATED STORY: Border Patrol: Man caught leading 2 horses carrying drugs]

Friday afternoon at the DeConcini crossing, officers referred a 38-year-old man for further inspection. His Saturn sedan was searched and officers seized more than 21 pounds of cocaine from the vehicle's firewall. The cocaine was worth an estimated at $239,200.

On Saturday, officers at the Mariposa Commercial Facility referred a 65-year-old man for further inspection.

The suspect was driving a tractor-trailer which was inspected, leading to a discovery of more than 364 pounds of meth worth almost $1,092,300, six pounds of heroin worth more than $100,000, almost seven pounds of fentanyl valuing at more than $95,000, and a suspected 6,000 oxycodone pills at a value of nearly $113,000.

"The third largest seizure of its kind by a CBP port of entry in Arizona," says CBP regarding the seizure on Saturday.

All drugs were seized from the vehicles and the two subjects were arrested, then turned over to Homeland Security Investigators.

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